Calorie restriction: is AMPK a key sensor and effector?

The effect of continuous training and intermittent calorie restriction (ICR) on miR-146a gene expression and TNF-α and IL-6 levels in obese women

Background and Objective: Obesity is a multifactorial disease in which environmental and genetic factors are involved. Disrupting homeostasis of lipid metabolism can cause multiple disorders. Among different mechanisms that cause interpersonal differences in obesity, epigenetic factors play a key role in the expression of related genes. Also, the effect of continuous training with caloric restr...

AMP-activated protein kinase and metabolic control.

AMP-activated protein kinase AMP-activated protein kinase (AMPK AMPK ), a phylogenetically conserved serine/threonine protein kinase, is a major regulator of cellular and whole-body energy homeostasis that coordinates metabolic pathways in order to balance nutrient supply with energy demand. It is now recognized that pharmacological activation of AMPK improves blood glucose homeostasis, lipid p...

The Effect of Peripheral Injection of Leptin on Biomarkers of Aging in Calorie Restricted Rats

Background and Objectives: Calorie restriction (CR) is one of the proven methods of extending lifespan and slowing aging. Leptin is a nutritionally regulated adipokine that has been proposed as a possible key signal in the adaptive responses relevant to CR. Under CR, plasma leptin levels decrease, thus it was hypothesized that leptin administration may counteract CR-induced weight loss. Therefo...

Calorie Restriction, Longevity and Cognitive Function

Loss of AMP-Activated Protein Kinase-α2 Impairs the Insulin-Sensitizing Effect of Calorie Restriction in Skeletal Muscle

Whether the well-known metabolic switch AMP-activated protein kinase (AMPK) is involved in the insulin-sensitizing effect of calorie restriction (CR) is unclear. In this study, we investigated the role of AMPK in the insulin-sensitizing effect of CR in skeletal muscle. Wild-type (WT) and AMPK-α2(-/-) mice received ad libitum (AL) or CR (8 weeks at 60% of AL) feeding. CR increased the protein le...